Data

Demonstrated A1C results across 3 different studies1-4

Mean change in A1C
from baseline at week 26

PIONEER 3
(vs. Januvia®)2

All + MET ± SU

Y-AXIS:
MEAN CHANGE IN A1C FROM BASELINE (%)

PIONEER 2
(vs. Jardiance®)3

Both + MET; open label

PIONEER 4
(vs. Victoza® and placebo)4

All + MET ± SGLT2i

At week 52, the mean changes from baseline for A1C were -1.2% (RYBELSUS® 14 mg),-0.9% (Victoza® 1.8 mg), and -0.2% (placebo).

Y-AXIS:
MEAN CHANGE IN A1C FROM BASELINE (%)

Demonstrated weight results across 3 different studies (2° endpoint)1-4

Mean change in weight
from baseline at week 26

PIONEER 3
(vs. Januvia®)2

All + MET ± SU

Y-AXIS:
MEAN CHANGE IN WEIGHT FROM BASELINE (kg)

RYBELSUS® is not indicated for weight reduction.

PIONEER 2
(vs. Jardiance®)3

Both + MET; open label

PIONEER 4
(vs. Victoza® and placebo)4

All + MET ± SGLT2i

At week 52, the mean changes from baseline in body weight were -4.3 kg (RYBELSUS® 14 mg), -3.0 kg (Victoza® 1.8 mg), and -1.0 kg (placebo).

Y-AXIS:
MEAN CHANGE IN WEIGHT FROM BASELINE (kg)

RYBELSUS® is not indicated for weight reduction.

Adapted from the RYBELSUS® Product Monograph;1 Pratley RE, et al., 2019,4 see back for study design (PIONEER 4); Rodbard H, et al., 2019,3 see back for study design (PIONEER 2); Rosenstock J, et al., 2019,2 see back for study design (PIONEER 3).

MET=metformin; NS=non-superiority; SGLT2i=sodium-glucose cotransporter-2 inhibitor; SU=sulfonylurea.

Dosing

Help patients start once-daily RYBELSUS®1

This regimen is intended to mitigate gastrointestinal symptoms during dose escalation.

No dose adjustment of RYBELSUS® is recommended based on age, sex, race, ethnicity, upper gastrointestinal disease, or hepatic and renal impairment.

Patients can take RYBELSUS® according to
the following instructions:1

Take on an empty stomach,
e.g., upon waking

Swallow tablet whole with no
more than half a glass of water
(up to 120 mL)

Patients can be counselled to
swallow the tablet whole with a
sip of water

A larger volume of water is
likely to decrease the amount of
RYBELSUS® absorbed

Wait at least 30 minutes before eating,
drinking, or taking any other
oral medication

Waiting <30 minutes is likely to decrease
the amount of RYBELSUS® absorbed

  • Tablets should not be split, crushed, or chewed

  • Tablets must be stored in their original blister pack to protect them from moisture and light

Missed dose: If a dose is missed, the missed dose should be skipped, and the next dose should be taken the following day.

For management of a suspected drug overdose, contact your regional poison control centre.

Please see the Product Monograph for complete dosing, administration, and overdosage information.

Downloads

RYBELSUS® Product Monograph

(March 30, 2020)

More resources will be added in the future

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