Data

Demonstrated A1C results across 3 different studies1-4
Mean change in A1C
from baseline at week 26
PIONEER 3
(vs. Januvia®)2
All + MET ± SU

Y-AXIS:
MEAN CHANGE IN A1C FROM BASELINE (%)
PIONEER 2
(vs. Jardiance®)3
Both + MET; open label

PIONEER 4
(vs. Victoza® and placebo)4
All + MET ± SGLT2i

At week 52, the mean changes from baseline for A1C were -1.2% (RYBELSUS® 14 mg),-0.9% (Victoza® 1.8 mg), and -0.2% (placebo).
Y-AXIS:
MEAN CHANGE IN A1C FROM BASELINE (%)

Demonstrated weight results across 3 different studies (2° endpoint)1-4
Mean change in weight
from baseline at week 26
PIONEER 3
(vs. Januvia®)2
All + MET ± SU

Y-AXIS:
MEAN CHANGE IN WEIGHT FROM BASELINE (kg)
RYBELSUS® is not indicated for weight reduction.
PIONEER 2
(vs. Jardiance®)3
Both + MET; open label

PIONEER 4
(vs. Victoza® and placebo)4
All + MET ± SGLT2i

At week 52, the mean changes from baseline in body weight were -4.3 kg (RYBELSUS® 14 mg), -3.0 kg (Victoza® 1.8 mg), and -1.0 kg (placebo).
Y-AXIS:
MEAN CHANGE IN WEIGHT FROM BASELINE (kg)
RYBELSUS® is not indicated for weight reduction.
Adapted from the RYBELSUS® Product Monograph;1 Pratley RE, et al., 2019,4 see back for study design (PIONEER 4); Rodbard H, et al., 2019,3 see back for study design (PIONEER 2); Rosenstock J, et al., 2019,2 see back for study design (PIONEER 3).
MET=metformin; NS=non-superiority; SGLT2i=sodium-glucose cotransporter-2 inhibitor; SU=sulfonylurea.
Dosing
Help patients start once-daily RYBELSUS®1


This regimen is intended to mitigate gastrointestinal symptoms during dose escalation.
No dose adjustment of RYBELSUS® is recommended based on age, sex, race, ethnicity, upper gastrointestinal disease, or hepatic and renal impairment.
Patients can take RYBELSUS® according to
the following instructions:1
Take on an empty stomach,
e.g., upon waking
Swallow tablet whole with no
more than half a glass of water
(up to 120 mL)
Patients can be counselled to
swallow the tablet whole with a
sip of water
A larger volume of water is
likely to decrease the amount of
RYBELSUS® absorbed
Wait at least 30 minutes before eating,
drinking, or taking any other
oral medication
Waiting <30 minutes is likely to decrease
the amount of RYBELSUS® absorbed
-
Tablets should not be split, crushed, or chewed
-
Tablets must be stored in their original blister pack to protect them from moisture and light
Missed dose: If a dose is missed, the missed dose should be skipped, and the next dose should be taken the following day.
For management of a suspected drug overdose, contact your regional poison control centre.
Please see the Product Monograph for complete dosing, administration, and overdosage information.
Downloads

RYBELSUS® Product Monograph
(March 30, 2020)
More resources will be added in the future
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